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(B) An antibody molecule is $Y$-shaped and consists of four polypeptide chains: two light chains and two heavy chains.Each polypeptide chain has two e

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$N$-terminal

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(B) An antibody molecule is $Y$-shaped and consists of four polypeptide chains: two light chains and two heavy chains.Each polypeptide chain has two ends: an $N$-terminal (amino terminal) and a $C$-terminal (carboxyl terminal).The antigen-binding site is located at the variable region of the antibody,which is situated at the $N$-terminal ends of both the heavy and light chains.Therefore,the $N$-terminal end is responsible for binding with the antigen.

Column-$I$	Column-$II$
$(a)$ Physical barrier	$(1)$ Skin
$(b)$ Physiological barrier	$(2)$ Interferon protein
$(c)$ Cellular barrier	$(3)$ Leucocytes
$(d)$ Cytokine barrier	$(4)$ Saliva in the mouth

Which terminal end of the antibody protein structure is responsible for binding with the antigen?

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Column-$I$ Column-$II$

$(a)$ Physical barrier $(1)$ Skin

$(b)$ Physiological barrier $(2)$ Interferon protein

$(c)$ Cellular barrier $(3)$ Leucocytes

$(d)$ Cytokine barrier $(4)$ Saliva in the mouth

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