A : Non-competitive inhibitors have no effect | vedclass

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Question

(D) Non-competitive inhibitors bind to an allosteric site (a site other than the active site) on the enzyme,which changes the conformation of the enzy

Vedclass · Accepted Answer

Both Assertion and Reason are incorrect.

Vedclass · Answer

(D) Non-competitive inhibitors bind to an allosteric site (a site other than the active site) on the enzyme,which changes the conformation of the enzyme such that the active site becomes less effective. This binding does not prevent substrate binding but reduces the catalytic rate,thereby decreasing the maximum velocity $(V_{max})$ of the reaction. Therefore,the Assertion is incorrect. The Reason is also incorrect because,in non-competitive inhibition,the inhibitor and substrate bind at different sites,not the same site. Thus,both Assertion and Reason are incorrect.

$A$ : Non-competitive inhibitors have no effect on $V_{max}$.
$R$ : In non-competitive inhibition,inhibitor and substrate bind at same sites on the enzyme.

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$A$ : Non-competitive inhibitors have no effect on $V_{max}$.$R$ : In non-competitive inhibition,inhibitor and substrate bind at same sites on the enzyme.