$A$ : Insulin is not given orally.
$R$ : Insulin hormone is lipid soluble and directly enters inside the cell membrane.

Nobel prize winner $E.W. Sutherland$ demonstrated:

Receptors are made up of $.......$.

Given below are two statements: one is labelled as Assertion $(A)$ and the other is labelled as Reason $(R)$.
Assertion $(A)$: $FSH$,which interacts with membrane-bound receptors,does not enter the target cell.
Reason $(R)$: Binding of $FSH$ to its receptors generates a second messenger (cyclic $AMP$) for its biochemical and physiological responses.
In the light of the above statements,choose the most appropriate answer from the options given below:

Epinephrine is.....

. . . . . . are responsible for chemical coordination.