$pBR322$ was the first artificial cloning vector developed in $...A...$ by $...B...$ and $...C...$ from $E. coli$ plasmid. Here $A, B$ and $C$ can be:

Restriction endonucleases are:

Restriction endonucleases are enzymes that:

The first restriction endonuclease type $II$,$...A..$,was isolated by Smith,Wilcox and Kelley from $...B...$ bacterium. It was found to cut $DNA$ molecules at a particular point by recognizing a specific sequence of six base pairs,known as the $...C....$. Here $A, B$ and $C$ can be:

Given below are two statements:
Statement $I:$
Restriction endonucleases recognise specific sequences to cut $DNA$,known as palindromic nucleotide sequences.
Statement $II:$
Restriction endonucleases cut the $DNA$ strand a little away from the centre of the palindromic site.
In the light of the above statements,choose the most appropriate answer from the options given below:

The vector for $T-DNA$ is