A: Sickle cell anaemia occurs due to a point | vedclass

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(C) Sickle cell anaemia is caused by a point mutation in the $\beta$-globin gene of haemoglobin.
In the normal $Hb^A$ gene,the codon is $GAG$,which c

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Assertion and Reason both are correct and Reason is the correct explanation of Assertion.

Vedclass · Answer

(C) Sickle cell anaemia is caused by a point mutation in the $\beta$-globin gene of haemoglobin.
In the normal $Hb^A$ gene,the codon is $GAG$,which codes for Glutamic acid.
In the mutant $Hb^S$ gene,a point mutation changes $GAG$ to $GUG$ in the $mRNA$.
This results in the substitution of Valine for Glutamic acid at the sixth position of the $\beta$-globin chain.
Therefore,the Assertion is correct,but the Reason is incorrect because it states the codons in reverse ($GAG$ instead of $GUG$ for $Hb^S$).

$A$: Sickle cell anaemia occurs due to a point mutation.
$R$: $mRNA$ produced from the $Hb^S$ gene has $GUG$ instead of $GAG$.

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$A$: Sickle cell anaemia occurs due to a point mutation. $R$: $mRNA$ produced from the $Hb^S$ gene has $GUG$ instead of $GAG$.