Which of the following genotypes causes sickl | vedclass

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(A) Sickle cell anemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carriers

Vedclass · Accepted Answer

$Hb^S Hb^S$

Vedclass · Answer

(A) Sickle cell anemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carriers for the gene $(Hb^A Hb^S)$.In this disease,the defect is caused by the substitution of Glutamic acid $(Glu)$ by Valine $(Val)$ at the sixth position of the beta-globin chain of the hemoglobin molecule.The genotype $Hb^S Hb^S$ represents the affected individual (homozygous recessive),who suffers from the disease.The genotype $Hb^A Hb^A$ represents a normal individual.The genotype $Hb^A Hb^S$ represents a carrier individual who is phenotypically normal but carries the trait.Therefore,the genotype that causes the disease is $Hb^S Hb^S$.

Which of the following genotypes causes sickle cell anemia?

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