Who suggested the proteinaceous nature of enzymes?

Jacob and Monod named those enzymes allosteric whose activity is regulated by

The Michaelis constant $(K_m)$ value of an enzyme is the substrate concentration at which the velocity of the reaction is:

$A$: Enzymes have high molecular weight and complex structures.
$R$: Every enzyme possesses all the properties associated with proteins.

Enzymes as they exist inside the cell are

Which of the following statements is $NOT$ associated with enzymes?