What causes immunodeficiency?

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(B) Immunodeficiency is a state in which the immune system's ability to fight infectious diseases and cancer is compromised or entirely absent.$1$. $A

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Defective thymus gland

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(B) Immunodeficiency is a state in which the immune system's ability to fight infectious diseases and cancer is compromised or entirely absent.$1$. $A$ defective thymus gland leads to a deficiency in $T$-lymphocytes,which are crucial for cell-mediated immunity.$2$. Without a functional thymus,the maturation of $T$-cells is impaired,resulting in a severe immunodeficiency disorder.$3$. While the $AIDS$ virus $(HIV)$ also causes immunodeficiency,the most fundamental biological cause related to the development of the immune system itself is the failure of the thymus gland.

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