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Question

(B) The starting material contains a ketone group and an acetal (cyclic ketal) protecting group. To reduce the ketone to an alkane without affecting t

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Wolff-Kishner reduction

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(B) The starting material contains a ketone group and an acetal (cyclic ketal) protecting group. To reduce the ketone to an alkane without affecting the acetal,we must use conditions that are stable in basic media. Clemmensen reduction uses $Zn(Hg)/HCl$,which is acidic and would hydrolyze the acetal. Wolff-Kishner reduction uses $NH_2NH_2/KOH$,which is basic. Acetals are stable in basic media,making Wolff-Kishner reduction the correct choice for this transformation.

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