Certain pathogens are tissue/organ specific. Justify the statement with suitable examples.

(N/A) Pathogens often exhibit tissue or organ specificity,meaning they target particular sites within the host body to survive and multiply.
$1$. $Salmonella \ typhi$ is a pathogen that specifically infects the small intestine,leading to typhoid fever.
$2$. In contrast,the intestinal endoparasite $Entamoeba \ histolytica$ specifically targets the large intestine,causing amoebic dysentery.
These examples demonstrate that different pathogens have evolved to thrive in specific physiological environments within the human body.