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(D) During the process of mitosis, the $Prophase$ stage is characterized by the initiation of condensation of chromosomal material. As the cell progre

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late prophase

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(D) During the process of mitosis, the $Prophase$ stage is characterized by the initiation of condensation of chromosomal material. As the cell progresses into $late prophase$, the nuclear envelope, nucleolus, Golgi complex, and endoplasmic reticulum $(ER)$ begin to disappear. These structures completely disintegrate by the end of $prophase$ to allow the spindle fibers to attach to the kinetochores of the chromosomes.

During mitosis, the $ER$ and nucleolus begin to disappear at:

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