| $T$-lymphocytes | $B$-lymphocytes |
| $(1)$ They form the cell-mediated immune system $(CMIS)$. | $(1)$ They form the humoral or antibody-mediated immune system $(AMIS)$. |
| $(2)$ They fight against pathogens,including intracellular parasites,viruses,and fungi that infect cells. | $(2)$ They fight against pathogens like bacteria and viruses that circulate in blood and lymph. |
| $(3)$ Upon activation,they differentiate into killer $(cytotoxic)$,helper,and suppressor $T$-cells. | $(3)$ Upon activation,they differentiate into plasma cells (which produce antibodies) and memory $B$-cells. |
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