How is a mature,functional insulin hormone di | vedclass

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Question

(A) Insulin is synthesized as a prohormone (pro-insulin),which contains an extra stretch of amino acids called the $C$-peptide. This $C$-peptide is no

Vedclass · Accepted Answer

The prohormone contains an extra $C$-peptide chain.

Vedclass · Answer

(A) Insulin is synthesized as a prohormone (pro-insulin),which contains an extra stretch of amino acids called the $C$-peptide. This $C$-peptide is not present in the mature,functional insulin hormone. During the maturation process,the $C$-peptide is removed,and the remaining $A$ and $B$ polypeptide chains are linked by disulfide bridges to form the active hormone. The main challenge in the production of insulin using $rDNA$ technology was getting the two chains assembled into a mature,functional form.

How is a mature,functional insulin hormone different from its prohormone form?

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