In gene therapy of adenosine deaminase $\text{(ADA)}$ deficiency,the patient requires periodic infusion of genetically engineered lymphocytes because:
- AGene isolated from marrow cells producing $\text{ADA}$ is introduced into cells at embryonic stages.
- BLymphocytes from patient's blood are grown in culture,outside the body.
- CRetroviral vector is introduced into these lymphocytes.
- DGenetically engineered lymphocytes are not immortal cells.
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