In sickle-cell anaemia,which of the following | vedclass

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(A) Sickle-cell anaemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carrier

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Glutamic acid by valine in $\beta$-chain

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(A) Sickle-cell anaemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carriers for the gene.This disease is controlled by a single pair of allele,$Hb^A$ and $Hb^S$.The defect is caused by the substitution of Glutamic acid $(Glu)$ by Valine $(Val)$ at the sixth position of the $\beta$-globin chain of the haemoglobin molecule.This substitution occurs due to the single base pair substitution at the sixth codon of the $\beta$-globin gene from $GAG$ to $GUG$.

In sickle-cell anaemia,which of the following amino acids is substituted?

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