Lesch-Nyhan disease is an X-linked recessive | vedclass

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(A) Lesch-Nyhan disease is an $X$-linked recessive disorder. In males,the frequency of the affected phenotype is equal to the frequency of the recessi

Vedclass · Accepted Answer

$0.96$

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(A) Lesch-Nyhan disease is an $X$-linked recessive disorder. In males,the frequency of the affected phenotype is equal to the frequency of the recessive allele $(q)$.Given that the number of affected males is $20$ out of $500$,the frequency of the affected allele $(q)$ is calculated as:$q = \frac{20}{500} = \frac{1}{25} = 0.04$.According to the Hardy-Weinberg principle,$p + q = 1$,where $p$ is the frequency of the normal (dominant) allele and $q$ is the frequency of the recessive (affected) allele.Therefore,$p = 1 - q = 1 - 0.04 = 0.96$.The frequency of the normal allele is $0.96$.

Lesch-Nyhan disease is an $X$-linked recessive disorder that causes neurological damage in human beings. $A$ survey of $500$ males from a Caucasian population revealed that $20$ were affected with this disorder. What is the frequency of the normal allele in this population?

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