Loss of choline acetyltransferase occurs in

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(D) $Alzheimer's$ disease is a neurodegenerative disorder characterized by the presence of senile plaques and neurofibrillary tangles in the brain. Th

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Alzheimer's disease

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(D) $Alzheimer's$ disease is a neurodegenerative disorder characterized by the presence of senile plaques and neurofibrillary tangles in the brain. These pathological changes lead to a significant reduction in the activity of the enzyme choline acetyltransferase,which is responsible for the synthesis of the neurotransmitter acetylcholine. This loss of acetylcholine contributes to the cognitive decline and memory impairment observed in patients with $Alzheimer's$ disease.

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