The major checkpoint of the cell cycle is:

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(A) The cell cycle is regulated by specific control points known as checkpoints. The most critical checkpoint,often referred to as the 'restriction po

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$G_1 \rightarrow S$ transition

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(A) The cell cycle is regulated by specific control points known as checkpoints. The most critical checkpoint,often referred to as the 'restriction point' or 'start',occurs at the $G_1 \rightarrow S$ transition. At this stage,the cell commits to $DNA$ replication and division based on internal and external signals. Another significant checkpoint exists at the $G_2 \rightarrow M$ transition,which ensures that $DNA$ replication is complete and accurate before the cell enters mitosis.

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