Mark the incorrect statement.

People who have migrated from the plains to an area adjoining Rohtang Pass about six months back:

Which two of the following changes $(i-iv)$ usually tend to occur in plain dwellers when they move to high altitudes ($3,500 \ m$ or more)?
$(i)$ Increase in red blood cell size
$(ii)$ Increase in red blood cell production
$(iii)$ Increased breathing rate
$(iv)$ Increase in thrombocyte count
Changes occurring are

Describe the metabolic processes of living organisms in relation to gas exchange.

Which of the following statements are not correct?
$I.$ Diffusion membrane is made up of $3$ layers
$II.$ Solubility of $CO_{2}$ in blood is higher than $O_{2}$ by $25$ times
$III.$ Breathing volumes are estimated by spirometer
$IV.$ High $H^{+}$ in blood favours oxygen dissociation
Choose the correct option

Assertion: In mammals,a complex respiratory system has developed.
Reason: Mammalian skin is impermeable to gases.