(D) The primordial germ cells (PGCs) are the precursors of gametes. In humans, these cells originate from the endoderm of the $yolk sac$ during early

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(D) The primordial germ cells (PGCs) are the precursors of gametes. In humans, these cells originate from the endoderm of the $yolk sac$ during early embryonic development. From the $yolk sac$, these cells migrate to the developing gonads (ovaries or testes) to differentiate into $oogonia$ or $spermatogonia$, respectively.