What is the correct order of reactivity of ca | vedclass

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(B) The reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution depends on the leaving group ability of the group attached to

Vedclass · Accepted Answer

$R-CO-X > R-CO-O-CO-R > R-CO-OR > R-CONH_2$

Vedclass · Answer

(B) The reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution depends on the leaving group ability of the group attached to the acyl carbon. The better the leaving group,the more reactive the derivative. The order of leaving group ability is $Cl^- > RCOO^- > RO^- > NH_2^-$. Therefore,the order of reactivity is $R-CO-Cl > R-CO-O-CO-R > R-CO-OR > R-CONH_2$.

What is the correct order of reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution?

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