Philadelphia chromosome is

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(B) The correct answer is $B$. The Philadelphia chromosome is an abnormal chromosome found in the cells of patients with chronic myeloid leukemia $(CM

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$22^{nd}$ chromosome

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(B) The correct answer is $B$. The Philadelphia chromosome is an abnormal chromosome found in the cells of patients with chronic myeloid leukemia $(CML)$.It was discovered in $1960$ by researchers in Philadelphia,who observed that it resulted from a reciprocal translocation between chromosome $9$ and chromosome $22$,specifically denoted as $t(9;22)(q34;q11)$.This translocation creates a fusion gene,$BCR-ABL1$,which leads to the production of a constitutively active tyrosine kinase,driving the uncontrolled proliferation of white blood cells.

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