(D) Physical or mental dependence on a specific substance (e.g.,alcohol,drugs) that leads to a compulsion to increase its use is known as $Addiction$.

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(D) Physical or mental dependence on a specific substance (e.g.,alcohol,drugs) that leads to a compulsion to increase its use is known as $Addiction$.$Addiction$ is a chronic,relapsing disorder characterized by compulsive drug seeking and use despite adverse consequences.