Receptors for protein hormones are located

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(B) Protein hormones,as well as peptide and amino acid derivative hormones,are generally water-soluble and cannot pass through the lipid bilayer of th

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On cell surface

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(B) Protein hormones,as well as peptide and amino acid derivative hormones,are generally water-soluble and cannot pass through the lipid bilayer of the plasma membrane.Therefore,they bind to specific receptor molecules located on the cell surface (plasma membrane) of target cells.This binding triggers the generation of second messengers (like $cAMP$ or $Ca^{2+}$) inside the cell to carry out the hormonal response.

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