Sickle cell anaemia disorder arises due to

Name: Exam Paper Generator | JEE NEET Paper Generator | Vedclass
Brand: Vedclass
Rating: 5 (35 reviews)

Question

(B) Sickle cell anaemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carrier

Vedclass · Accepted Answer

Substitution in a single base of $DNA$

Vedclass · Answer

(B) Sickle cell anaemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carriers for the gene.This disease is controlled by a single pair of allele,$Hb^A$ and $Hb^S$.It is caused by a point mutation in the $\beta$-globin chain of the haemoglobin molecule.Specifically,there is a substitution of Glutamic acid $(Glu)$ by Valine $(Val)$ at the sixth position of the $\beta$-globin chain.This substitution occurs due to a single base pair change in the $DNA$ sequence,where the codon $GAG$ is mutated to $GUG$.

Similar Questions

Explain thalassemia.

Which of the following most accurately describes hemophilia?

Quantitative defect of hemoglobin $- P$
Qualitative defect of hemoglobin $- Q$
Select the correct option for $P$ and $Q$.
$\quad \quad P\quad \quad \quad Q$

Study the pedigree chart given below. What does it show?

An affected male marries a normal female. They have three daughters and five sons. All the daughters are affected,and all the sons are normal. The gene for this disease is:

Vedclass Test Series

Exam Paper Generator

Online Exam Module