Sickle-cell anaemia happens due to A mutation | vedclass

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Question

(A) Sickle-cell anaemia is a classic example of a point mutation.It occurs due to a single base pair substitution in the gene coding for the $\beta$-g

Vedclass · Accepted Answer

$A-$point; $B-\beta$-chain

Vedclass · Answer

(A) Sickle-cell anaemia is a classic example of a point mutation.It occurs due to a single base pair substitution in the gene coding for the $\beta$-globin chain of haemoglobin.Specifically, the codon $GAG$ is replaced by $GUG$, which leads to the substitution of glutamic acid with valine at the sixth position of the $\beta$-globin chain.Therefore, $A$ is point mutation and $B$ is $\beta$-chain.

Sickle-cell anaemia happens due to $A$ mutation in which $B$ of haemoglobin is affected. Fill the correct option for $A$ and $B$.

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