Sickle-cell anaemia is caused by the followin | vedclass

Name: Exam Paper Generator | JEE NEET Paper Generator | Vedclass
Brand: Vedclass
Rating: 5 (35 reviews)

Question

(A) The correct answer is $GAG-GUG$ (at the mRNA level) or $CTC-CAC$ (at the $DNA$ template strand level).In sickle-cell anaemia,a point mutation occu

Vedclass · Accepted Answer

$CTC$-$CAC$

Vedclass · Answer

(A) The correct answer is $GAG-GUG$ (at the mRNA level) or $CTC-CAC$ (at the $DNA$ template strand level).In sickle-cell anaemia,a point mutation occurs in the $\beta$-globin gene.Specifically,the codon $GAG$ (coding for glutamic acid) is mutated to $GUG$ (coding for valine) at the sixth position of the $\beta$-globin chain.At the $DNA$ level,the template strand codon $CTC$ is mutated to $CAC$,which results in the transcription of $GUG$ instead of $GAG$.This substitution of valine for glutamic acid causes the haemoglobin molecules to polymerize under low oxygen tension,leading to the characteristic sickle shape of the red blood cells.

Sickle-cell anaemia is caused by the following mutant gene mutation ($DNA$ level):

Similar Questions

Color blindness is a ..... trait.

What is sickle-cell anemia?

Which one of the following symbols represents mating between relatives in human pedigree analysis?

Phenylketonuria is a genetic disorder due to a defect in the metabolism of which of the following?

Which hereditary disease condition is characterized by the failure of blood to coagulate?

Vedclass Test Series

Exam Paper Generator

Online Exam Module