(C) Sickle-cell anaemia is a genetic disorder caused by a point mutation in the $HbA$ gene located on chromosome $11$.This mutation leads to the subst

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(C) Sickle-cell anaemia is a genetic disorder caused by a point mutation in the $HbA$ gene located on chromosome $11$.This mutation leads to the substitution of glutamic acid with valine at the sixth position of the $\beta$-globin chain of haemoglobin.Since it is caused by a change in the $DNA$ sequence,it is classified as a genetic disease.