What are the effects of regular use of drugs or alcohol?

(N/A) The immediate adverse effects of drug and alcohol abuse are manifested in the form of reckless behavior,vandalism,and violence.
Excessive doses of drugs may lead to coma and death due to respiratory failure,heart failure,or cerebral hemorrhage.
$A$ combination of drugs or their intake along with alcohol generally results in overdosing and even deaths.
The most common warning signs of drug and alcohol abuse among youth include a drop in academic performance,unexplained absence from school/college,lack of interest in personal hygiene,withdrawal,isolation,depression,fatigue,aggressive and rebellious behavior,deteriorating relationships with family and friends,loss of interest in hobbies,and changes in sleeping and eating habits,weight,and appetite.