What are transgenic bacteria? Illustrate using any one example.

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(N/A) Transgenic bacteria are those that contain a foreign gene intentionally introduced into their genome.
They are genetically manipulated to express a desirable gene for the production of various commercially important products.
An example of transgenic bacteria is $E. coli$. In the plasmid of $E. coli$,two $DNA$ sequences corresponding to the $A$ and $B$ chains of human insulin are inserted to produce the respective human insulin chains.
After the insertion of the insulin gene into the bacterium,it becomes transgenic and starts producing chains of human insulin.
Later,these chains are extracted from $E. coli$ and combined to form mature human insulin.

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Match the following columns.
Column-$I$ Column-$II$
$(A)$ Gene therapy $(1)$ Effort to fix a functional gene
$(B)$ Humulin $(2)$ $A$ single-stranded $DNA$ or $RNA$ tagged with a radioactive molecule
$(C)$ Probe $(3)$ Diagnostic test
$(D)$ $ELISA$ $(4)$ Diabetes

Match the following and choose the correct option$-$
Column $I$ Column $II$
$(a)$ Eli Lilly $(i)$ Bacillus thuringiensis
$(b)$ Bt $(ii)$ Human insulin
$(c)$ Gene therapy $(iii)$ Meloidogyne incognita
$(d)$ $\text{RNAi}$ $(iv)$ Adenosine deaminase deficiency

From which organism was insulin extracted in earlier times?

Match the following columns:
List-$I$List-$II$
$(a)$ $1977$$(1)$ Creation of the first transgenic cow
$(b)$ $1983$$(2)$ American company obtained patent for Basmati rice
$(c)$ $1990$$(3)$ Eli Lilly company prepared two $DNA$ sequences for insulin
$(d)$ $1997$$(4)$ First clinical gene therapy trial

Which human hormone was the first to be produced using recombinant $DNA$ technology?

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