Which of the following is most reactive for n | vedclass

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(D) The reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution depends on the leaving group ability.The leaving group abilit

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$CH_3COCl$

Vedclass · Answer

(D) The reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution depends on the leaving group ability.The leaving group ability is inversely proportional to the basicity of the leaving group.The order of leaving group ability is $Cl^{-} > CH_3COO^{-} > C_2H_5O^{-} > NH_2^-$.Therefore,the reactivity order is: $	ext{Acid chloride} > 	ext{Acid anhydride} > 	ext{Ester} > 	ext{Amide}$.Thus,$CH_3COCl$ is the most reactive.

Which of the following is most reactive for nucleophilic substitution reaction?

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