Which of the following is not associated with | vedclass

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(D) The life cycle of the malaria parasite $(Plasmodium)$ in humans involves two main phases: the exo-erythrocytic cycle (which includes the pre-eryth

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Metacryptozoite

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(D) The life cycle of the malaria parasite $(Plasmodium)$ in humans involves two main phases: the exo-erythrocytic cycle (which includes the pre-erythrocytic cycle) and the erythrocytic cycle.$1$. The pre-erythrocytic cycle occurs in the liver cells.$2$. The sporozoites enter the liver cells and transform into cryptozoites.$3$. These cryptozoites undergo multiple fission,known as schizogony,to produce crypto-merozoites.$4$. Metacryptozoites are formed during the exo-erythrocytic cycle in the liver,but they are specifically associated with the secondary cycle (exo-erythrocytic) that occurs after the initial pre-erythrocytic phase,or are sometimes considered part of the broader liver stage. However,in standard terminology,the term 'metacryptozoite' is often distinguished from the initial 'cryptozoite' phase of the pre-erythrocytic cycle.$5$. Among the given options,'Metacryptozoite' is the stage that follows the initial pre-erythrocytic development and is associated with the secondary liver cycle,making it the least directly associated with the primary pre-erythrocytic cycle.

Column-$I$	Column-$II$
$(a)$ Pre-erythrocytic cycle	$(1)$ Meta-cryptomerozoites enter $RBC$ and become spherical in shape.
$(b)$ Exo-erythrocytic cycle	$(2)$ Sporozoites in saliva are introduced into human blood.
$(c)$ Endo-erythrocytic cycle	$(3)$ Breaks the liver cells and comes out into the blood.

Which of the following is not associated with the pre-erythrocytic cycle of the malaria parasite?

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