Which of the following peptide chain is removed during the maturation of proinsulin into insulin?

  • A
    $A$-chain ($21$ amino acids)
  • B
    $B$-chain ($30$ amino acids)
  • C
    $C$-chain ($33$ amino acids)
  • D
    $A$ and $B$ chains

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Which country's company first produced human insulin?

Consider the following statements about insulin.
$I.$ Human insulin is made up of $51$ amino acids arranged in two polypeptide chains.
$II.$ The two polypeptide chains are interconnected by two disulphide bridges.
$III.$ In mammals,including humans,insulin is synthesised as a pro-hormone,which contains an extra stretch called the $C$-peptide.
$IV.$ $C$-peptide is not present in the mature insulin.
Which of the statements given above are correct?

Which protein production was successfully introduced in $E. coli$?

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What is the demerit of using bovine insulin (from cow) and porcine insulin (from pig) in diabetic patients?

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