Which one of the following flows directly into blood from the seat of its production to act on an organ away from it?

Which of the following is not a protein hormone?

Match the following columns.

Column-$I$	Column-$II$
$(A)$ Oxytocin	$(1)$ Amino acid derivatives
$(B)$ Epinephrine	$(2)$ Steroid
$(C)$ Progesterone	$(3)$ Protein
$(D)$ Growth hormone	$(4)$ Peptide

$I.$ Autocrine hormones $II.$ Endocrine hormones $III.$ Paracrine hormones
Among them, which one is/are local regulator(s) and do not travel through the blood?

Given below are two statements.
Statement $I$: Mode of action of catecholamines,peptide and polypeptide hormones is through cell membrane receptors.
Statement $II$: These hormones are non-steroid,water soluble and lipid insoluble hormones.
In the light of above statements,choose the correct option from below:

Steroid hormones typically alter the activity of target cells by