Which one of the following hormones never reaches the cytoplasm of target cells?

Which of the following hormones never enters the cytoplasm of the target cell?

Action of the peptide hormone on a target cell is mediated by

Chemically,hormones are composed of ........

Identify the correct receptors for the following hormones:
$\quad$ $\quad$ Peptide hormone $\quad$ $\quad$ Epinephrine

Given below are two statements.
Statement $I$: Mode of action of catecholamines,peptide and polypeptide hormones is through cell membrane receptors.
Statement $II$: These hormones are non-steroid,water soluble and lipid insoluble hormones.
In the light of above statements,choose the correct option from below: