In sickle-cell anemia,what is the sequence of | vedclass

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Question

(B) Sickle-cell anemia is caused by a point mutation in the $\beta$-globin gene of hemoglobin.In the normal gene,the template strand has the sequence

Vedclass · Accepted Answer

$GTG$

Vedclass · Answer

(B) Sickle-cell anemia is caused by a point mutation in the $\beta$-globin gene of hemoglobin.In the normal gene,the template strand has the sequence $CTC$,which codes for $GAG$ in mRNA,resulting in the amino acid Glutamic acid.In the mutated gene,the $CTC$ sequence on the template strand changes to $CAC$.Consequently,the non-template (coding) strand,which carries the same sequence as the mRNA (except $T$ instead of $U$),changes from $GAG$ to $GTG$.Therefore,the defective sequence on the non-template strand is $GTG$.

Column-$I$	Column-$II$
$(A)$ $DNA$ replication	$(p)$ $RNA$ polymerase
$(B)$ Translation	$(q)$ $DNA$ polymerase
$(C)$ Transcription	$(r)$ Reverse transcriptase
$(D)$ Reverse transcription	$(s)$ Aminoacyl synthetase

List $I$	List $II$
$A$. Frederick Griffith	$I$. Genetic code
$B$. Francois Jacob and Jacques Monod	$II$. Semi-conservative mode of $DNA$ replication
$C$. Har Gobind Khorana	$III$. Transformation
$D$. Meselson and Stahl	$IV$. $Lac$ operon

In sickle-cell anemia,what is the sequence of the defective nitrogen base on the $DNA$ strand that does not act as a template?

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