Why are histone proteins positively charged?

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Question

(D) Histones are a group of basic proteins that associate with $DNA$ in the chromatin. They are rich in the basic amino acids $Lysine$ and $Arginine$.

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Arginine and Lysine

Vedclass · Answer

(D) Histones are a group of basic proteins that associate with $DNA$ in the chromatin. They are rich in the basic amino acids $Lysine$ and $Arginine$. These amino acids carry positive charges in their side chains at physiological $pH$. Since $DNA$ is negatively charged due to the phosphate groups in its backbone,the positively charged histones are attracted to it,allowing for the packaging of $DNA$ into nucleosomes.

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