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(A) The first clinical gene therapy was performed in $1990$ on a $4$-year-old girl suffering from Adenosine Deaminase $(ADA)$ deficiency.$ADA$ enzyme

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Adenosine Deaminase $(ADA)$ deficiency

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(A) The first clinical gene therapy was performed in $1990$ on a $4$-year-old girl suffering from Adenosine Deaminase $(ADA)$ deficiency.$ADA$ enzyme is crucial for the proper functioning of the immune system.In this therapy,lymphocytes from the patient's blood were grown in a culture outside the body.$A$ functional $ADA$ $cDNA$ was then introduced into these lymphocytes using a retroviral vector.These genetically engineered lymphocytes were subsequently returned to the patient's body.Since these cells are not immortal,the patient requires periodic infusion of such genetically engineered lymphocytes.

The first clinical gene therapy was given in $1990$ to a $4$-year-old girl for the treatment of which disease?

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