Which of the following enzymes is NOT regulat | vedclass

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(C) Calcium $(Ca^{2+})$ acts as a secondary messenger and regulates many enzymes, often by binding to calmodulin. $1$. Nitric oxide synthase is regula

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Adenylate kinase

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(C) Calcium $(Ca^{2+})$ acts as a secondary messenger and regulates many enzymes, often by binding to calmodulin. $1$. Nitric oxide synthase is regulated by $Ca^{2+}/calmodulin$. $2$. Protein phosphatase (specifically calcineurin) is regulated by $Ca^{2+}$. $3$. Adenylate kinase is an enzyme involved in maintaining cellular energy homeostasis by catalyzing the reaction $2ADP \rightleftharpoons ATP + AMP$. It is not regulated by calcium. $4$. Fructose isomerase (phosphoglucose isomerase) is a glycolytic enzyme and is not regulated by calcium. However, in the context of standard biochemical regulation, Adenylate kinase is the classic example of an enzyme not dependent on $Ca^{2+}$ signaling for its activity.

Which of the following enzymes is $NOT$ regulated by calcium?

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