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Question

(B) The reaction involves the reduction of a carbonyl group $(C=O)$ to a methylene group $(CH_2)$.$1$. Clemmensen reduction $(Zn(Hg), HCl)$ is acidic

Vedclass · Accepted Answer

$NH_2-NH_2/KOH/\Delta$

Vedclass · Answer

(B) The reaction involves the reduction of a carbonyl group $(C=O)$ to a methylene group $(CH_2)$.$1$. Clemmensen reduction $(Zn(Hg), HCl)$ is acidic and would hydrolyze the acetal/thioacetal protecting group.$2$. Wolff-Kishner reduction $(NH_2-NH_2/KOH/\Delta)$ is basic and is suitable for reducing carbonyls in the presence of base-stable protecting groups like acetals or thioacetals.$3$. $LiAlH_4$ would reduce the carbonyl to an alcohol.$4$. $H_2/Ni$ would reduce the carbonyl to an alcohol.Therefore,the correct reagent is $NH_2-NH_2/KOH/\Delta$.

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