Anaphase Promoting Complex (APC) is a protein | vedclass

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(B) $APC$ (Anaphase Promoting Complex) is an E3 ubiquitin ligase that triggers the transition from metaphase to anaphase by tagging specific proteins

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Chromosomes will not segregate.

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(B) $APC$ (Anaphase Promoting Complex) is an E3 ubiquitin ligase that triggers the transition from metaphase to anaphase by tagging specific proteins (like securin and cyclin $B$) for degradation. Securin degradation releases the enzyme separase,which cleaves the cohesin proteins holding sister chromatids together. If $APC$ is defective,these proteins are not degraded,cohesin remains intact,and sister chromatids fail to separate. Therefore,the chromosomes will not segregate to opposite poles.

Anaphase Promoting Complex $(APC)$ is a protein degradation machinery necessary for proper mitosis of animal cell. If $APC$ is defective in a human cell,which of the following is expected to occur?

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