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(A) : Haemophilia is a sex-linked recessive disease,also known as bleeder's disease. In this condition,a single protein involved in the cascade of blo

Vedclass · Accepted Answer

It is a dominant disease.

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(A) : Haemophilia is a sex-linked recessive disease,also known as bleeder's disease. In this condition,a single protein involved in the cascade of blood clotting is affected (e.g.,antihaemophilic globulin or factor $VIII$ in haemophilia-$A$,or plasma thromboplastin factor $IX$ in haemophilia-$B$). Because the patient lacks these essential clotting factors,even a minor cut leads to continuous bleeding,which can be fatal. It is caused by a recessive gene $h$ located on the $X$-chromosome. $A$ female becomes haemophiliac only if both her $X$-chromosomes carry the recessive gene $(X^hX^h)$. $A$ female with one recessive allele $(XX^h)$ is a carrier and appears normal because the dominant allele on the other $X$-chromosome ensures normal clotting. Males are more frequently affected because they have only one $X$-chromosome $(X^hY)$,meaning a single recessive gene is sufficient to express the disease.

Select the incorrect statement with regard to haemophilia.

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