Sickle-cell anaemia has not been eliminated f | vedclass

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Question

(C) Sickle-cell anaemia is a genetic disorder caused by a mutation in the haemoglobin gene. In regions where malaria is endemic,such as parts of Afric

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Provides immunity against malaria

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(C) Sickle-cell anaemia is a genetic disorder caused by a mutation in the haemoglobin gene. In regions where malaria is endemic,such as parts of Africa,individuals who are heterozygous for the sickle-cell trait (carriers) possess a survival advantage. This is because the presence of some abnormal haemoglobin interferes with the life cycle of the malaria parasite $(Plasmodium)$,thereby providing partial immunity or resistance against malaria. Consequently,the gene for sickle-cell anaemia is maintained in the population through natural selection.

Column $I$	Column $II$
$(a)$ Sickle cell anaemia	$(x)$ Homogentisic acid
$(b)$ Alkaptonuria	$(y)$ Melanin pigments are absent
$(c)$ Albinism	$(z)$ More amount of phenylalanine
$(d)$ Phenylketonuria	$(w)$ Defective haemoglobin

Sickle-cell anaemia has not been eliminated from the African population because it

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Column $I$ Column $II$

$(a)$ Sickle cell anaemia $(x)$ Homogentisic acid

$(b)$ Alkaptonuria $(y)$ Melanin pigments are absent

$(c)$ Albinism $(z)$ More amount of phenylalanine

$(d)$ Phenylketonuria $(w)$ Defective haemoglobin

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