Which of the following is used in biotechnology?

Explain the use of biotechnology in various fields.

The transfer of the streptomycin resistance gene from $Nicotiana$ $tabacum$ to $Nicotiana$ $sylvestris$ was achieved through which method?

Read the following four statements and identify the two incorrect statements:
$(1)$ The first transgenic buffalo,Rosie,produced milk enriched with human alpha-lactalbumin.
$(2)$ $DNA$ is isolated from large molecules using restriction enzymes.
$(3)$ Downstream processing is a stage of $r$-$DNA$ technology.
$(4)$ Disarmed pathogen vectors are also used to transfer $r$-$DNA$ into the host.

Match the following columns:

Column-$I$	Column-$II$
$(a)$ Pest resistant plant	$(1)$ Transgenic cow
$(b)$ Golden rice	$(2)$ $C$-peptide
$(c)$ Proinsulin	$(3)$ High vitamin $A$ content
$(d)$ Rosie	$(4)$ $RNA$ interference

Which of the following may be considered as an application of biotechnology?