Which of the following is mismatched?

Read the following four statements $(A-D)$.
$(A)$ Colostrum is recommended for the new born because it is rich in antibodies.
$(B)$ Chikungunya is caused by a Gram-negative bacterium.
$(C)$ Tissue culture has proved useful in obtaining virus-free plants.
$(D)$ Beer is manufactured by distillation of fermented grape juice.
How many of the above statements are wrong?

$A$ - The puffed-up appearance of dough is due to the production of $CO_2$ gas.
$R$ - $LAB$ damages the stomach.

Match the following columns:

Column-$I$	Column-$II$
$1$. $Propionibacterium$ $shermanii$	$A$. Production of ethanol from fruit juice
$2$. $Saccharomyces$ $cerevisiae$	$B$. Citric Acid
$3$. $Aspergillus$ $niger$	$C$. 'Swiss Cheese'
$4$. $Trichoderma$ $polysporum$	$D$. Immunosuppressive agent

Match the following columns:

Column-$I$	Column-$II$
$(a)$ Distillation	$(1)$ Rhizobium
$(b)$ Non-distillation	$(2)$ Azotobacter
$(c)$ Symbiotic	$(3)$ Beer and Wine
$(d)$ Free-living	$(4)$ Whisky,Brandy,Rum

Microbes can be used to decrease the use of chemical fertilisers and pesticides. Explain how this can be accomplished.